Preheat the oven to 350ºF. Whisk breadcrumbs, milk, and egg in a small bowl
Mix ground beef, parsley, oregano, garlic powder, onion powder, red pepper flakes, salt, and pepper in a large bowl until just combined.
Add breadcrumb mixture and mix until just combined.
Spread the meat into an 8 x 10-inch rectangle on some parchment paper.
Layer with the ham slices, followed by the slices of cheese.
Gently roll up the meat. Seal the edges.
Place meatloaf into a baking dish, seam side down. Top with tomato sauce.
Bake for 45-60 minutes. Take the meatloaf out of the oven and top with extra cheese slices. Turn on your oven's broiler. Broil the meatloaf until the cheese is melted.
Remove from oven, cover with tented foil and let the meatloaf rest for 5-10 minutes before serving.
** Making the breadcrumb mixture first and allowing it to sit for several minutes lets the milk and egg saturate the crumbs and will help keep your meatloaf moist.
** Don't use ground beef with low fat content. Fat helps keep the meatloaf succulent, so aim for 25 to 30 percent fat content.
** If you're worried about your meatloaf drying out, you can add a dollop of mustard, ketchup, or a splash of Worcestershire sauce to the recipe
** Don't skip the resting step! Resting the meatloaf before cutting it helps it to stay moist.
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